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Likewise, in the PU.1 (-/-) /SOD1 G93A mice unable to synthesize myeloid cells, the replacement of microglia, monocyte, and macrophage lineages with genotypically identical wild type cells slows disease progression and extends overall survival (Beers et al., 2006), suggesting that non cell-autonomous effects contribute to ALS progression independently of disease onset

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Methylation of the epsilon (ε) amino group of lysine is catalyzed by one or more protein:lysine methyltransferases