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Some of the findings in studies conducted in our laboratory are also inconsistent with Freter’s nutrient niche hypothesis (83, 84, 117)
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Higher expression of xCT in the proximity of dentate gyrus and subventricular region has been found to meet the higher requirement of GSH by proliferating neuronal progenitor cells whereas, extracellular glutamate release can cause excitotoxicity in differentiated neurons 15,17
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