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While still a useful method for oxylipin measurement, the predominant application has shifted away from GC-MS with the advent of LC coupled to electrospray ionization (ESI)

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555,556 Lifestyle modifications include head-up tilt sleeping, which elevates the head of the bed by 10–30° to reduce nocturnal diuresis and improve morning orthostatic tolerance, and advising patients to avoid triggers such as prolonged standing, sudden postural changes, high ambient temperatures, and large meals that may exacerbate symptoms