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In particular, VD analogs such as cholecalciferol, calcitriol, and paricalcitol demonstrated a significant improvement in renal function in two RCTs, possibly due to their ability to bypass the renal-dependent 1-alphahydroxylation process
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[14] Genetics [edit] The enzyme is coded by the gene with the symbol MTHFR on chromosome 1 location p36.3 in humans
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