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Item Volume::11.8 Fluid Ounce

While choline was first isolated in the 1860s, its biological importance wasn’t fully appreciated until the 20th century.26 In 1998, the Institute of Medicine officially classified it as an essential nutrient — highlighting its vital roles in liver health, cell signaling, and brain development.11 Since then, research on choline has expanded significantly, influencing dietary guidelines and supplement formulations.1 Different types of choline supplements Choline appears in supplements under several different names