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What sets Sec apart from all other amino acids is that in eukaryotes, it is uniquely synthesized directly on its own specialized tRNA, known as tRNA [Ser]Sec , which works in collaboration with a unique RNA structure in the 3′ untranslated region of the mRNA known as the Sec Insertion Sequence (SECIS) element, and several essential protein cofactors

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Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig