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376 Gold compounds such as [Au(C–C-2-NC 5 H 4 )(PTA)] induce colorectal carcinoma cell death via ROS-mediated necroptosis by activating and signaling and also have been shown to exert an immunosuppressive role by inhibiting IB kinase activation and promoting cell apoptosis

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This paradox may be partially explained by the cellular source: endothelial NOS (eNOS)-derived NO appears protective, while inducible NOS (iNOS) from macrophages tends to promote fibrosis [83]