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In adipose thermogenesis, the increase in β3-AR expression revealed the important role of cAMP signaling, where the thermogenic genes, such as Ucp1 , Cidea , PPARγc1α , PPARγ2 , and Pdk4 , were suppressed in the WAT and BAT of Adipo-Gsα-KO-mice [61,62]
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227,229 In AD, autophagy defects mediate the disruption of protein homeostasis networks (production and extracellular secretion of Aβ, abnormal aggregation of tau protein) and lead to the accumulation of damaged organelles, such as dysfunctional mitochondria
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