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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression ( Gclc and Gclm ( Gclc and Gclm , supporting the conclusion that melatonin augments NRF2 transcriptional activity in ILC2s
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doi: 10.1002/ps.6040 21 EdgarR
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