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On day 15, 30 minutes after administration of the treatments, animals performed the Morris water maze test

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The observed changes at both the SDL and coils/turns of the β-propeller could, therefore, result in functional alteration in ligand-binding affinity at the ‘RGD’’-binding site (i.e., site I), leading to binding of αvβ3 integrin-specific extracellular matrix (ECM) ligands to site I