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For those reasons, the upper tolerable limit for daily Se consumption to prevent chronic toxicity was set to 300–450 μg by various guidelines, including the IOM, SCF, WHO/FAO, and the UK Expert Group on Vitamins and Minerals (51)

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While these studies show that cell shape can affect the rate of diffusion, even more fundamentally, the diffusion coefficient of cAMP itself has been questioned both experimentally and computationally 837,844,848