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for review, see Sikiric et al., 2018) persists against the notion of continuous, direct injury (increased intra-abdominal hypertension) and shows that organs may adequately function despite continuously elevated intra-abdominal pressure

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One study (Shi et al., 2019, mice treated for 11 weeks with a dose equivalent to 144 mg/kg bw day) reported increased fasting plasma insulin (about 150% of control) and decreased insulin sensitivity ( 28.2 g/day 41 ) gained more weight (1.4 kg, SE = 0.4, p = 0.02) than subjects in the lowest tertile (0 g/day)