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Osteosarcoma CGA reduces the proliferation of osteosarcoma cell lines such as U2OS, MG-63, and Saos-2 by increasing the activity of caspase-3, caspase-7, and PARP, and inducing apoptosis through the blockage of the STAT3/Snail pathway [294,295]

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The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway