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These cells secrete proinflammatory cytokines, including IFN-Ξ³, IL-1Ξ², IL-12, CCL4, CCL5, and GM-CSF, which are associated with hepatocyte damage, increased ROS production, apoptosis, and activation of JAK-STAT1/3 and NF-ΞΊB signaling pathways (109)
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