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The best characterised outcome of caspase-4/-5/-11 activation is GSDMD cleavage, resulting in the potent inflammatory form of cell death, pyroptosis, which would significantly exacerbate this inflammatory condition

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Because expression levels of both nucleoporins Ran-binding protein 2 (RanBP2) and Ran-GTPase-activating protein 1 (RanGAP1) on the nuclear envelope are upregulated in the epidermis of psoriatic lesion, adequate expression of these nuclear envelope proteins is likely a prerequisite for nucleocytoplasmic transport in keratinocytes of the psoriatic epidermis (86)