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These results suggest that upon depletion of GSH, tissues undergo reprogramming to hyperactivate NRF2, possibly as a mechanism to upregulate adjacent antioxidant pathways and buffer oxidative stress induced upon GSH depletion

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Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi/Chinese Journal of Integrated Traditional & Western Medicine/Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban 2002;22(6):414‐6