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Similarly, the optimal timing for microbiota-based interventions-including preventive strategies before stroke onset, as well as interventions during the acute phase or chronic recovery stage-remains unclear

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In a SURMOUNT-1 trial of obese adults without diabetes, tirzepatide at dosages of 5, 10, or 15 mg reduced weight by an average of 15.0%, 19.5%, and 20.9%, respectively, compared with only 3.1% in those receiving a placebo [70]