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89,133–135 Numerous studies have reported that misfolded proteins and protein aggregates, including tau, 136–139 Aβ, 138,140 α-synuclein, 141–144 mutant huntingtin, 145 TDP-43, 132,146 superoxide dismutase 1 (SOD1), 147–149 and fused in sarcoma (FUS) 150 induce microglial activation and neuroinflammation

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